Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.59 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | ULK1 | O75385 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20598291 | 1.00 | IRAK4 (0.59) | IRAK4IRAK1KMT2AMEN1MAPT | |
| SCHEMBL20598157 | 0.85 | IRAK4 (0.65) | IRAK4IRAK1KMT2AMEN1MAPT | |
| SCHEMBL20598761 | 0.84 | IRAK4 (0.59) | IRAK4IRAK1KMT2AMEN1MAPT | |
| SCHEMBL30501503 | 0.84 | IRAK4 (0.59) | IRAK4IRAK1KMT2AMEN1MAPT | |
| SCHEMBL20598729 | 0.82 | CSF1R (0.49) | IRAK4KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL20598523 | 0.81 | NTRK1 (0.56) | IRAK4KMT2AMEN1MAPT | |
| SCHEMBL30501370 | 0.78 | NPC1 (0.65) | KMT2AMEN1MAPTALDH1A1PKM | |
| SCHEMBL20598315 | 0.78 | NPC1 (0.65) | KMT2AMEN1MAPTALDH1A1PKM | |
| SCHEMBL16106421 | 0.78 | MAPT (0.58) | KMT2AMEN1MAPTALDH1A1PKM | |
| SCHEMBL20598629 | 0.76 | IRAK4 (0.63) | IRAK4IRAK1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | disclosed |