Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25172564 | 1.00 | MAPT (0.45) | MAPTHTR6CYP3A4CYP2D6THRB | |
| SCHEMBL1272497 | 0.86 | MAPT (0.50) | MAPTTHRBSLC9A1LMNAKMT2A | |
| SCHEMBL22915922 | 0.81 | KLK7 (0.43) | MAPTHTR6SLC9A1LMNAKMT2A | |
| SCHEMBL30302198 | 0.80 | NR1H2 (0.49) | MAPTHTR6SLC9A1LMNAKMT2A | |
| SCHEMBL2144861 | 0.78 | MAPT (0.50) | MAPTHTR6THRBSLC9A1LMNA | |
| SCHEMBL15910233 | 0.76 | HTR6 (0.47) | HTR6CYP3A4CYP2D6THRBLMNA | |
| SCHEMBL30661141 | 0.76 | HTR6 (0.47) | HTR6CYP3A4CYP2D6THRBLMNA | |
| SCHEMBL25169357 | 0.74 | HTR6 (0.47) | MAPTHTR6THRBSLC9A1LMNA | |
| SCHEMBL31571431 | 0.74 | HTR6 (0.55) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL23589255 | 0.74 | HTR6 (0.55) | HTR6CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426688-A1 | DDR1 AND DDR2 INHIBITORS FOR THE TREATEMENT OF CANCER AND FIBROTIC DISEASES | Redx Pharma Plc (GB) | 2024-09-11 | — | — | EP | disclosed |
| CN-118201918-A | DDR1 and DDR2 inhibitors for the treatment of cancer and fibrotic diseases | 莱德克斯制药公共有限公司 | 2024-06-14 | — | — | CN | disclosed |
| WO-2023079291-A1 | DDR1 AND DDR2 INHIBITORS FOR THE TREATEMENT OF CANCER AND FIBROTIC DISEASES | REDX PHARMA PLC (GB) | 2023-05-11 | — | — | WO | disclosed |