SCHEMBL3050342

SCHEMBL3050342

O=C1CC2CCC(C2)N1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7789990 0.86 MAPK1 (0.30)
SCHEMBL1741558 0.85 ITGB3 (0.33)
SCHEMBL3053192 0.79
SCHEMBL7787819 0.77 MAPK1 (0.30)
SCHEMBL7630156 0.71
SCHEMBL5269896 0.71
SCHEMBL6712898 0.70
SCHEMBL23733563 0.67
SCHEMBL22469372 0.67
SCHEMBL22527339 0.67 BLM (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2791135-B1 ANABASINE DERIVATIVES TARGETING THE NICOTINIC ACETYLCHOLINE RECEPTORS UNIV FLORIDA (US) 2018-06-06 EP disclosed
US-9150558-B2 Nicotine receptor targeted compounds and compositions UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-10-06 US disclosed
US-9150558-B2 Nicotine receptor targeted compounds and compositions UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-10-06 US disclosed
US-9150558-B2 Nicotine receptor targeted compounds and compositions UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-10-06 US disclosed
US-20140343042-A1 NICOTINE RECEPTOR TARGETED COMPOUNDS AND COMPOSITIONS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 2014-11-20 US disclosed
US-20140343042-A1 NICOTINE RECEPTOR TARGETED COMPOUNDS AND COMPOSITIONS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 2014-11-20 US disclosed
US-20140343042-A1 NICOTINE RECEPTOR TARGETED COMPOUNDS AND COMPOSITIONS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 2014-11-20 US disclosed
EP-2791135-A1 NICOTINIC RECEPTOR TARGETED COMPOUNDS AND COMPOSITIONS University of Florida Research Foundation (US) 2014-10-22 EP disclosed
WO-2013090260-A1 NICOTINIC RECEPTOR TARGETED COMPOUNDS AND COMPOSITIONS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) 2013-06-20 WO disclosed
WO-2013090260-A1 NICOTINIC RECEPTOR TARGETED COMPOUNDS AND COMPOSITIONS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) 2013-06-20 WO disclosed
US-6071906-A INHIBITS OR MODULATES THE INDUCIBLE ISOFORM OF NITRIC OXIDE SYNTHASE OVER THE THE CONSTITUTIVE ISOFORMS; ANTIARTHRITIC, -DIABETIC, ISCHEMIC, THROMBOSIS AGENTS; CARDIOVASCULAR DISORDERS; TOXIC SHOCK SYNDROME; AUTOIMMUNE DISEASES G. D. SEARLE & CO. (US) 2000-06-06 US disclosed
US-6046211-A TREATMENT OF ARTHRITIS OR INFLAMMATORY BOWEL DISEASE, CARDIOVASCULAR ISCHEMIA, DIABETES, HYPERALGESIA (ALLODYNIA), CEREBRAL ISCHEMIA AND OTHER CNS DISORDERS G.D. SEARLE & CO. (US) 2000-04-04 US disclosed
EP-0968198-A1 HETEROCYCLIC COMPOUNDS AND THEIR USE FOR INHIBITING $g(b)-AMYLOID PEPTIDE Elan Pharmaceuticals, Inc. (US) 2000-01-05 EP disclosed
WO-1999067221-A1 COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS ELAN PHARMACEUTICALS, INC. (US) 1999-12-29 WO disclosed
EP-0951466-A2 CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS Elan Pharmaceuticals, Inc. (US) 1999-10-27 EP disclosed
EP-0724570-B1 AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS SEARLE & CO (US) 1999-03-03 EP disclosed
EP-0897912-A1 Amidino derivatives useful as nitric oxide synthase inhibitors G.D. SEARLE & CO. (US) 1999-02-24 EP disclosed
WO-1998038177-A1 HETEROCYCLIC COMPOUNDS AND THEIR USE FOR INHIBITING β-AMYLOID PEPTIDE ELAN PHARMACEUTICALS, INC. (US) 1998-09-03 WO disclosed
WO-1998028268-A2 CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS AS β-AMYLOID PEPTIDE RELEASE INHIBITORS ELAN PHARMACEUTICALS, INC. (US) 1998-07-02 WO disclosed
WO-1995011231-A1 AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS G. D. SEARLE & CO. (US) 1995-04-27 WO disclosed