Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22401276 | 1.00 | STK17B (0.50) | STK17BSTK17ASYKALDH1A1KDM4E | |
| SCHEMBL29076116 | 0.83 | ALDH1A1 (0.49) | STK17BSTK17ASYKALDH1A1KDM4E | |
| SCHEMBL30504113 | 0.80 | STK17B (0.51) | STK17BSTK17ASYKALDH1A1KDM4E | |
| SCHEMBL22401330 | 0.80 | STK17B (0.51) | STK17BSTK17ASYKALDH1A1KDM4E | |
| SCHEMBL22866255 | 0.80 | ALDH1A1 (0.55) | SYKALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL34462297 | 0.79 | MAPT (0.54) | STK17BSTK17ASYKALDH1A1KDM4E | |
| SCHEMBL2523948 | 0.77 | SYK (0.53) | SYKALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL11582962 | 0.77 | ALDH1A1 (0.52) | SYKALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL12942870 | 0.76 | SYK (0.64) | STK17BSTK17ASYKALDH1A1MEN1 | |
| SCHEMBL28684686 | 0.76 | ALDH1A1 (0.51) | SYKALDH1A1KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527084-B | Isofuranone compounds useful as HPK1 inhibitors | 百时美施贵宝公司 | 2023-07-18 | — | — | CN | disclosed |