Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13036669 | 0.86 | CTSK (0.49) | CTSKCA1CA2BTKHSD11B1 | |
| SCHEMBL30504919 | 0.84 | CTSK (0.49) | CTSKCA1CA2BTKHSD11B1 | |
| SCHEMBL17207638 | 0.84 | CTSK (0.49) | CTSKCA1CA2BTKHSD11B1 | |
| SCHEMBL30504918 | 0.84 | CTSK (0.49) | CTSKCA1CA2BTKHSD11B1 | |
| SCHEMBL17207727 | 0.84 | CTSK (0.49) | CTSKCA1CA2BTKHSD11B1 | |
| SCHEMBL1699916 | 0.83 | CTSK (0.61) | CTSKCA1CA2BTKHSD11B1 | |
| SCHEMBL1699915 | 0.83 | CTSK (0.61) | CTSKCA1CA2BTKHSD11B1 | |
| SCHEMBL1808105 | 0.83 | CTSK (0.61) | CTSKCA1CA2BTKHSD11B1 | |
| SCHEMBL12794288 | 0.83 | CTSK (0.52) | CTSKCA1CA2BTKHSD11B1 | |
| SCHEMBL12794285 | 0.83 | CTSK (0.52) | CTSKCA1CA2BTKHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159322-A1 | QUINAZOLINE DERIVATIVES AS INHIBITORS OF THE GCN2 KINASE, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2023-08-31 | — | — | WO | disclosed |