Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.42 |
| ▸ | HTR7 | P34969 | 7/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.42 |
| ▸ | HTR6 | P50406 | 5/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.38 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25319509 | 1.00 | HTR1A (0.42) | HTR1AHTR7HTR2AHTR6IP6K1 | |
| SCHEMBL25319636 | 1.00 | HTR1A (0.42) | HTR1AHTR7HTR2AHTR6IP6K1 | |
| SCHEMBL30506829 | 1.00 | HTR1A (0.42) | HTR1AHTR7HTR2AHTR6IP6K1 | |
| SCHEMBL25315441 | 1.00 | HTR1A (0.42) | HTR1AHTR7HTR2AHTR6IP6K1 | |
| SCHEMBL30506972 | 1.00 | HTR1A (0.42) | HTR1AHTR7HTR2AHTR6IP6K1 | |
| SCHEMBL25314767 | 0.91 | HTR1A (0.46) | HTR1AHTR7HTR2AHTR6IP6K1 | |
| SCHEMBL30507163 | 0.91 | HTR1A (0.46) | HTR1AHTR7HTR2AHTR6IP6K1 | |
| SCHEMBL30506835 | 0.85 | HTR1A (0.44) | HTR1AHTR7HTR2AHTR6IP6K1 | |
| SCHEMBL25315499 | 0.85 | HTR1A (0.44) | HTR1AHTR7HTR2AHTR6IP6K1 | |
| SCHEMBL25318732 | 0.83 | IP6K1 (0.43) | HTR1AHTR7HTR2AHTR6IP6K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024249254-A2 | METHODS OF USING APOL1 INHIBITORS | MAZE THERAPEUTICS, INC. (US) | 2024-12-05 | — | — | WO | disclosed |
| EP-4465982-A2 | APOL1 INHIBITORS AND METHODS OF USE | Maze Therapeutics, Inc. (US) | 2024-11-27 | — | — | EP | disclosed |
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |