Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.53 |
| ▸ | MERTK | Q12866 | 4/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 11/20 | 0.52 |
| ▸ | BMPR1B | O00238 | 10/20 | 0.52 |
| ▸ | BMPR1A | P36894 | 10/20 | 0.52 |
| ▸ | ACVRL1 | P37023 | 10/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.52 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30508363 | 0.90 | AXL (0.52) | AXLMERTKLRRK2ACVR1BMPR1B | |
| SCHEMBL30508238 | 0.83 | LRRK2 (0.57) | AXLMERTKLRRK2ACVR1BMPR1B | |
| SCHEMBL18611468 | 0.83 | AXL (0.55) | AXLMERTKLRRK2ACVR1BMPR1B | |
| SCHEMBL18616317 | 0.82 | ACVR1 (0.56) | AXLMERTKACVR1BMPR1BBMPR1A | |
| SCHEMBL29042028 | 0.82 | ACVR1 (0.67) | AXLMERTKACVR1BMPR1BBMPR1A | |
| SCHEMBL30508297 | 0.82 | ACVR1 (0.67) | AXLMERTKACVR1BMPR1BBMPR1A | |
| SCHEMBL30508325 | 0.80 | ACVR1 (0.67) | AXLMERTKACVR1BMPR1BBMPR1A | |
| SCHEMBL29041913 | 0.80 | ACVR1 (0.67) | AXLMERTKACVR1BMPR1BBMPR1A | |
| SCHEMBL29042029 | 0.80 | AXL (0.58) | AXLMERTKLRRK2ACVR1BMPR1B | |
| SCHEMBL30508265 | 0.80 | AXL (0.58) | AXLMERTKLRRK2ACVR1BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478145-B | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116478145-A | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2023-07-25 | — | — | CN | disclosed |