Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.58 |
| ▸ | MERTK | Q12866 | 4/20 | 0.58 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.52 |
| ▸ | IKBKE | Q14164 | 5/20 | 0.51 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.50 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.50 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.50 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29042029 | 1.00 | AXL (0.58) | AXLMERTKTBK1LRRK2IKBKE | |
| SCHEMBL30508238 | 0.87 | LRRK2 (0.57) | AXLMERTKTBK1LRRK2IKBKE | |
| SCHEMBL18611468 | 0.87 | AXL (0.55) | AXLMERTKTBK1LRRK2IKBKE | |
| SCHEMBL30508270 | 0.86 | LRRK2 (0.56) | AXLMERTKLRRK2MAP4K1MAPK1 | |
| SCHEMBL29041987 | 0.86 | LRRK2 (0.56) | AXLMERTKLRRK2MAP4K1MAPK1 | |
| SCHEMBL30508414 | 0.85 | BMPR1B (0.64) | TBK1IKBKEACVR1BMPR1BBMPR1A | |
| SCHEMBL29152375 | 0.85 | BMPR1B (0.64) | TBK1IKBKEACVR1BMPR1BBMPR1A | |
| SCHEMBL31027897 | 0.82 | SMN1; SMN2 (0.50) | AXLMERTKMAPK1SMN1; SMN2HRH3 | |
| SCHEMBL4126100 | 0.82 | MAP4K1 (0.65) | AXLMAP4K1 | |
| SCHEMBL29041913 | 0.82 | ACVR1 (0.67) | AXLMERTKACVR1BMPR1BBMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478145-B | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116478145-A | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2023-07-25 | — | — | CN | disclosed |