Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | WHR1 | P49842 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25911938 | 0.85 | TLR8 (0.44) | TLR8NPC1ALDH1A1MAPTHTT | |
| SCHEMBL11890643 | 0.84 | TLR8 (0.44) | TLR8HDAC8NPC1ALDH1A1MAPT | |
| SCHEMBL2265239 | 0.84 | TLR8 (0.40) | TLR8KDM5AOGAGSK3BDYRK1A | |
| SCHEMBL29041967 | 0.78 | IRAK4 (0.43) | TLR8GSK3BDYRK1ANPC1ALDH1A1 | |
| SCHEMBL25339190 | 0.78 | TLR8 (0.40) | TLR8HDAC8NPC1ALDH1A1MAPT | |
| SCHEMBL20135108 | 0.78 | TLR8 (0.57) | TLR8HTT | |
| SCHEMBL30122249 | 0.78 | IRAK4 (0.41) | TLR8ALDH1A1MAPTHTT | |
| Hydrochloric Acid SCHEMBL30508248 | 0.77 | TLR8 (0.56) | TLR8HTT | |
| SCHEMBL25338343 | 0.77 | TLR8 (0.44) | TLR8HDAC8NPC1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL28215605 | 0.77 | TLR8 (0.56) | TLR8HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478145-B | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116478145-A | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2023-07-25 | — | — | CN | disclosed |