Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25379234 | 1.00 | CYP11B1 (0.43) | CYP11B1CYP11B2TGFBR1ARNR3C1 | |
| SCHEMBL26193080 | 0.85 | CSNK2A1 (0.39) | CYP11B1CYP11B2TGFBR1ARNR3C1 | |
| SCHEMBL26199143 | 0.83 | SCN4A (0.48) | CYP11B1CYP11B2ARNR3C1MEN1 | |
| SCHEMBL26193069 | 0.81 | TGFBR1 (0.37) | CYP11B1CYP11B2TGFBR1NR3C1CYP1A2 | |
| SCHEMBL30510213 | 0.81 | CYP11B1 (0.42) | CYP11B1CYP11B2ARNR3C1MEN1 | |
| SCHEMBL25378392 | 0.81 | CYP11B1 (0.42) | CYP11B1CYP11B2ARNR3C1MEN1 | |
| SCHEMBL30510067 | 0.79 | MEN1 (0.46) | CYP11B1CYP11B2TGFBR1ARMEN1 | |
| SCHEMBL25255928 | 0.79 | MEN1 (0.46) | CYP11B1CYP11B2TGFBR1ARMEN1 | |
| SCHEMBL25295233 | 0.78 | AR (0.41) | CYP11B1CYP11B2ARNR3C1KDM4E | |
| SCHEMBL30510117 | 0.78 | TGFBR1 (0.43) | CYP11B1CYP11B2TGFBR1CYP1A2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4452253-A2 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | The Katholieke Universiteit Leuven (BE) | 2024-10-30 | — | — | EP | disclosed |
| WO-2023122780-A9 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-11-30 | — | — | WO | disclosed |
| WO-2023122780-A2 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-06-29 | — | — | WO | disclosed |