Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | SQOR | Q9Y6N5 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | IL4 | P05112 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25380126 | 1.00 | SCN9A (0.44) | SCN9ACSNK2A1KDM4ETGFBR1SQOR | |
| SCHEMBL25379116 | 0.84 | SCN9A (0.40) | SCN9ACSNK2A1KDM4ETGFBR1SQOR | |
| SCHEMBL30510127 | 0.77 | KDM4E (0.45) | SCN9AKDM4EADORA2AMEN1ALDH1A1 | |
| SCHEMBL25376243 | 0.77 | KDM4E (0.45) | SCN9AKDM4EADORA2AMEN1ALDH1A1 | |
| SCHEMBL30510053 | 0.76 | KDM4E (0.50) | SCN9AKDM4ETGFBR1ALDH1A1HPGD | |
| SCHEMBL25375677 | 0.76 | KDM4E (0.50) | SCN9AKDM4ETGFBR1ALDH1A1HPGD | |
| SCHEMBL30510067 | 0.75 | MEN1 (0.46) | CSNK2A1KDM4ETGFBR1MEN1ALDH1A1 | |
| SCHEMBL25255928 | 0.75 | MEN1 (0.46) | CSNK2A1KDM4ETGFBR1MEN1ALDH1A1 | |
| SCHEMBL25375800 | 0.74 | TGFBR1 (0.43) | TGFBR1SCN4ACYP19A1 | |
| SCHEMBL30510117 | 0.74 | TGFBR1 (0.43) | TGFBR1SCN4ACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4452253-A2 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | The Katholieke Universiteit Leuven (BE) | 2024-10-30 | — | — | EP | disclosed |
| WO-2023122780-A9 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-11-30 | — | — | WO | disclosed |
| WO-2023122780-A2 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-06-29 | — | — | WO | disclosed |