Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21380995 | 1.00 | SCN9A (0.37) | SCN9AGPR119KCNH2FFAR4TLR9 | |
| SCHEMBL21381016 | 0.94 | GPR119 (0.36) | SCN9AGPR119KCNH2FFAR4MGLL | |
| SCHEMBL21381015 | 0.94 | GPR119 (0.36) | SCN9AGPR119KCNH2FFAR4MGLL | |
| SCHEMBL21381023 | 0.92 | GPR119 (0.39) | GPR119KCNH2FFAR4TLR9TLR8 | |
| SCHEMBL21381111 | 0.85 | GPR119 (0.39) | GPR119KCNH2FFAR4TLR9TLR8 | |
| SCHEMBL30510942 | 0.84 | GPR119 (0.45) | GPR119FFAR4 | |
| SCHEMBL21381031 | 0.84 | GPR119 (0.45) | GPR119FFAR4 | |
| SCHEMBL21381029 | 0.84 | GPR119 (0.45) | GPR119FFAR4 | |
| SCHEMBL21398052 | 0.83 | GPR119 (0.34) | GPR119KCNH2FFAR4TLR9TLR8 | |
| SCHEMBL21398243 | 0.83 | GPR119 (0.34) | GPR119KCNH2FFAR4TLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468967-B1 | COMPOUNDS CONTAINING BENZO[D][1,3]OXATHIOLE, BENZO[D][1,3]OXATHIOLE 3-OXIDE OR BENZO[D][1,3]OXATHIOLE 3,3-DIOXIDE AND METHODS/USES THEREOF AS AGONISTS OF G PROTEIN-COUPLED RECEPTOR 119 | PRAMANA PHARMACEUTICALS INC (CA) | 2023-07-26 | — | — | EP | disclosed |