Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.59 |
| ▸ | BTK | Q06187 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 16/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 16/20 | 0.53 |
| ▸ | PRKDC | P78527 | 16/20 | 0.53 |
| ▸ | ABL1 | P00519 | 15/20 | 0.53 |
| ▸ | HCK | P08631 | 15/20 | 0.53 |
| ▸ | SRC | P12931 | 15/20 | 0.53 |
| ▸ | KDR | P35968 | 15/20 | 0.53 |
| ▸ | MTOR | P42345 | 15/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 15/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.53 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.51 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5805229 | 0.87 | BTK (0.75) | EGFRBTKLCKLYNABL1 | |
| SCHEMBL23997146 | 0.86 | BTK (0.65) | EGFRBTKLCKLYNPIK3CD | |
| SCHEMBL5823929 | 0.85 | BTK (0.61) | EGFRBTKLCKLYNPIK3CD | |
| SCHEMBL24096496 | 0.85 | PIK3CD (0.61) | EGFRBTKLCKLYNPIK3CD | |
| SCHEMBL1317659 | 0.84 | LCK (0.73) | EGFRBTKLCKLYNPIK3CD | |
| SCHEMBL23997152 | 0.84 | LCK (0.69) | EGFRBTKLCKLYNPIK3CD | |
| SCHEMBL23997156 | 0.83 | LCK (0.71) | EGFRBTKLCKLYNPIK3CD | |
| SCHEMBL22720779 | 0.82 | BTK (0.70) | EGFRBTKLCKLYNABL1 | |
| SCHEMBL29439195 | 0.82 | BTK (0.70) | EGFRBTKLCKLYNABL1 | |
| SCHEMBL6430386 | 0.81 | BTK (0.61) | EGFRBTKLCKLYNSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116583287-A | Pyridazinone heterocyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-08-11 | — | — | CN | disclosed |