Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.73 |
| ▸ | CA9 | Q16790 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.69 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.67 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.66 |
| ▸ | DHCR7 | Q9UBM7 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3506177 | 1.00 | CA2 (0.73) | CA2CA9KDM4ETDP1ABCB1 | |
| SCHEMBL3174390 | 0.93 | CA2 (0.63) | CA2CA9KDM4ETDP1ABCB1 | |
| SCHEMBL3048278 | 0.89 | KDM4E (0.67) | CA2CA9KDM4ETDP1ABCB1 | |
| SCHEMBL3052881 | 0.89 | KDM4E (0.70) | CA2CA9KDM4ETDP1ABCB1 | |
| SCHEMBL3051837 | 0.89 | DHCR7 (0.67) | CA2CA9KDM4ETDP1ABCB1 | |
| SCHEMBL3059315 | 0.89 | ABCB1 (0.77) | CA2CA9KDM4ETDP1ABCB1 | |
| SCHEMBL3059233 | 0.88 | KDM4E (0.69) | CA2CA9KDM4ETDP1ABCB1 | |
| SCHEMBL3052036 | 0.88 | DHCR7 (0.80) | CA2CA9KDM4ETDP1ABCB1 | |
| SCHEMBL3041822 | 0.88 | CA2 (0.70) | CA2CA9KDM4ETDP1ABCB1 | |
| SCHEMBL3504140 | 0.88 | DHCR7 (0.79) | CA2CA9KDM4ETDP1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | claimed |
| US-8394825-B2 | Compound | STERIX LIMITED (GB) | 2013-03-12 | — | — | US | disclosed |
| US-8394825-B2 | Compound | STERIX LIMITED (GB) | 2013-03-12 | — | — | US | disclosed |
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | disclosed |
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | disclosed |
| EP-2155192-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | Sterix Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008117061-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | STERIX LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222299-A1 | COMPOUND | MKI67, VHL, MYC | CA2 1077/4885CA9 1002/4885KDM4E 1083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.