Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | APAF1 | O14727 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | TDP2 | O95551 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.49 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15537391 | 1.00 | KCNMA1 (0.53) | KCNMA1MAPTNPC1ALDH1A1APAF1 | |
| SCHEMBL13604189 | 0.77 | MAPT (0.47) | KCNMA1MAPTNPC1ALDH1A1APAF1 | |
| SCHEMBL19649394 | 0.74 | KCNMA1 (0.50) | KCNMA1MAPTNPC1ALDH1A1APAF1 | |
| SCHEMBL11406837 | 0.74 | MAPT (0.59) | MAPTNPC1ALDH1A1TDP1NPSR1 | |
| SCHEMBL15693720 | 0.73 | KCNMA1 (0.60) | KCNMA1MAPTNPC1ALDH1A1APAF1 | |
| SCHEMBL23840194 | 0.73 | KCNMA1 (0.64) | KCNMA1MAPTALDH1A1TDP1NPSR1 | |
| SCHEMBL25862494 | 0.73 | KCNMA1 (0.64) | KCNMA1MAPTALDH1A1NPSR1LMNA | |
| SCHEMBL31729992 | 0.72 | KCNMA1 (0.54) | KCNMA1MAPTNPC1ALDH1A1APAF1 | |
| SCHEMBL14483923 | 0.70 | KCNMA1 (0.49) | KCNMA1MAPTNPC1ALDH1A1APAF1 | |
| SCHEMBL14421241 | 0.70 | KCNMA1 (0.60) | KCNMA1MAPTNPC1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548022-B1 | COMPOSITIONS FOR MODULATING PD-1 SIGNAL TRANSDUCTION | UNIV RES INST INC AUGUSTA (US) | 2023-11-22 | — | — | EP | claimed |
| CN-116585315-A | Compositions for modulating PD-1 signaling | 奥古斯塔大学研究所公司 | 2023-08-15 | — | — | CN | claimed |
| CN-116585315-A | Compositions for modulating PD-1 signaling | 奥古斯塔大学研究所公司 | 2023-08-15 | — | — | CN | disclosed |