SCHEMBL30516214

SCHEMBL30516214

CN1CC(NC(=O)c2cc3nc(-c4cccc(F)c4)cc(-c4ccccc4)n3n2)C1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.64
HTT P42858 3/20 0.64
HPGD P15428 6/20 0.52
ALDH1A1 P00352 6/20 0.52
SMN1; SMN2 Q16637 2/20 0.51
GAA P10253 1/20 0.51
TP53 P04637 5/20 0.49
MAPT P10636 4/20 0.49
LMNA P02545 3/20 0.49
NPSR1 Q6W5P4 2/20 0.48
TDP1 Q9NUW8 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
MAPK1 P28482 2/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
OPRK1 P41145 2/20 0.47
PAOX Q6QHF9 2/20 0.47
ADRA2A P08913 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25970074 1.00 KDM4E (0.64) KDM4EHTTHPGDALDH1A1SMN1; SMN2
SCHEMBL25970078 0.91 KDM4E (0.68) KDM4EHTTHPGDALDH1A1SMN1; SMN2
SCHEMBL25969141 0.91 KDM4E (0.77) KDM4EHTTHPGDALDH1A1SMN1; SMN2
SCHEMBL25970069 0.87 KDM4E (0.62) KDM4EHTTHPGDALDH1A1SMN1; SMN2
SCHEMBL25970076 0.84 KDM4E (0.63) KDM4EHTTHPGDALDH1A1SMN1; SMN2
SCHEMBL30516230 0.84 KDM4E (0.63) KDM4EHTTHPGDALDH1A1SMN1; SMN2
SCHEMBL25335602 0.83 KDM4E (0.74) KDM4EHTTHPGDALDH1A1SMN1; SMN2
SCHEMBL25338396 0.83 KDM4E (0.74) KDM4EHTTHPGDALDH1A1SMN1; SMN2
SCHEMBL25968912 0.83 KDM4E (0.74) KDM4EHTTHPGDALDH1A1SMN1; SMN2
SCHEMBL25969943 0.83 KDM4E (0.64) KDM4EHTTHPGDALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4469454-A1 PYRAZOLOPYRIMIDINES AS MODULATORS OF SPERMINE OXIDASE Janssen Pharmaceutica NV (BE) 2024-12-04 EP disclosed
WO-2023141866-A1 PYRAZOLOPYRIMIDINES AS MODULATORS OF SPERMINE OXIDASE JANSSEN PHARMACEUTICA NV (BE) 2023-08-03 WO disclosed