Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.63 |
| ▸ | HTT | P42858 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SMOX | Q9NWM0 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25970076 | 1.00 | KDM4E (0.63) | KDM4EHTTALDH1A1HPGDNTRK1 | |
| SCHEMBL25969941 | 0.92 | KDM4E (0.63) | KDM4EHTTALDH1A1HPGDNTRK1 | |
| SCHEMBL30516221 | 0.92 | KDM4E (0.63) | KDM4EHTTALDH1A1HPGDNTRK1 | |
| SCHEMBL25969141 | 0.90 | KDM4E (0.77) | KDM4EHTTALDH1A1HPGDOPRK1 | |
| SCHEMBL25969943 | 0.87 | KDM4E (0.64) | KDM4EHTTALDH1A1HPGDOPRK1 | |
| SCHEMBL25970078 | 0.85 | KDM4E (0.68) | KDM4EHTTALDH1A1HPGDOPRK1 | |
| SCHEMBL30516214 | 0.84 | KDM4E (0.64) | KDM4EHTTALDH1A1HPGDOPRK1 | |
| SCHEMBL25970069 | 0.84 | KDM4E (0.62) | KDM4EHTTALDH1A1HPGDNTRK1 | |
| SCHEMBL25970074 | 0.84 | KDM4E (0.64) | KDM4EHTTALDH1A1HPGDOPRK1 | |
| SCHEMBL25338396 | 0.82 | KDM4E (0.74) | KDM4EHTTALDH1A1HPGDOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469454-A1 | PYRAZOLOPYRIMIDINES AS MODULATORS OF SPERMINE OXIDASE | Janssen Pharmaceutica NV (BE) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023141866-A1 | PYRAZOLOPYRIMIDINES AS MODULATORS OF SPERMINE OXIDASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-08-03 | — | — | WO | disclosed |