Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 8/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 5/20 | 0.36 |
| ▸ | BECN1 | Q14457 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | STAT3 | P40763 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19874090 | 1.00 | F11 (0.37) | F11KLKB1KLK1BCL2BECN1 | |
| SCHEMBL19874091 | 1.00 | F11 (0.37) | F11KLKB1KLK1BCL2BECN1 | |
| SCHEMBL19886605 | 0.90 | F11 (0.44) | F11KLKB1KLK1BCL2BECN1 | |
| SCHEMBL30517942 | 0.88 | F11 (0.41) | F11KLKB1KLK1BCL2BECN1 | |
| SCHEMBL19874158 | 0.87 | F11 (0.46) | F11KLKB1KLK1KDM4ERAB9A | |
| SCHEMBL19874161 | 0.87 | F11 (0.46) | F11KLKB1KLK1KDM4ERAB9A | |
| SCHEMBL19874124 | 0.83 | F11 (0.35) | F11KLK1BCL2BECN1KDM4E | |
| SCHEMBL17295748 | 0.82 | MEN1 (0.47) | KDM4ERAB9AMAPT | |
| SCHEMBL17295757 | 0.79 | F11 (0.46) | F11KLKB1KLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19874064 | 0.78 | F11 (0.60) | F11KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3500556-B1 | PYRIDINE-1-OXIDE DERIVATIVES AND THEIR USE AS FACTOR XIA INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-08-02 | — | — | EP | disclosed |