Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 12/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24433501 | 1.00 | NAMPT (0.56) | NAMPTGPR119KEAP1NFE2L2JAK2 | |
| SCHEMBL24433521 | 0.87 | PTPN2 (0.52) | NAMPTGPR119KEAP1NFE2L2JAK2 | |
| SCHEMBL24442760 | 0.87 | PTPN2 (0.49) | NAMPTGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL24433507 | 0.83 | JAK2 (0.49) | NAMPTGPR119JAK2JAK1CYP2C9 | |
| SCHEMBL29657073 | 0.83 | JAK2 (0.49) | NAMPTGPR119JAK2JAK1CYP2C9 | |
| SCHEMBL24433402 | 0.83 | JAK2 (0.51) | NAMPTGPR119JAK2JAK1CYP2C9 | |
| SCHEMBL30522718 | 0.83 | JAK2 (0.51) | NAMPTGPR119JAK2JAK1CYP2C9 | |
| SCHEMBL24433406 | 0.83 | MGLL (0.52) | — | |
| SCHEMBL24433399 | 0.83 | MGLL (0.52) | — | |
| SCHEMBL24433407 | 0.83 | MGLL (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547274-A | MAGL inhibitors | H.隆德贝克有限公司 | 2023-08-04 | — | — | CN | disclosed |