SCHEMBL30522975

C[C@@H]1CN(C(=O)C(=O)Nc2cncc3cnn(COCC[Si](C)(C)C)c23)[C@@H](c2ccc(F)cc2)CN1C(=O)OC(C)(C)C.C[C@@H]1CN[C@@H](c2ccc(F)cc2)CN1C(=O)OC(C)(C)C

nearest known ligand 0.31

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	NTRK1	P04629	2/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL25325008	0.94	NTRK1 (0.34)	NTRK1
SCHEMBL25325002	0.94	NTRK1 (0.34)	NTRK1
SCHEMBL30522949	0.94	NTRK1 (0.34)	NTRK1
SCHEMBL25327039	0.88	PRMT5 (0.38)	—
SCHEMBL25326285	0.87	PRMT5 (0.32)	—
SCHEMBL30522917	0.86	PRMT5 (0.36)	—
SCHEMBL25325945	0.81	PRMT5 (0.38)	—
SCHEMBL25326540	0.77	PIK3CA (0.31)	—
SCHEMBL25327238	0.75	PRMT5 (0.37)	NTRK1
SCHEMBL25327240	0.75	PRMT5 (0.37)	NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-4469445-A1	COMPOUNDS AND METHODS OF USE	Tango Therapeutics, Inc. (US)	2024-12-04	—	—	EP	disclosed