Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 11/20 | 0.51 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.50 |
| ▸ | IL2 | P60568 | 1/20 | 0.50 |
| ▸ | CLK1 | P49759 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30524645 | 0.83 | LRRK2 (0.62) | MAPK1MAP4K1IL2CLK1DYRK1A | |
| SCHEMBL1487526 | 0.78 | LRRK2 (0.59) | MAPK1MAP4K1IL2CLK1DYRK1A | |
| SCHEMBL31235685 | 0.78 | MAPK1 (0.59) | MAPK1MAP4K1IL2CLK1DYRK1A | |
| SCHEMBL18892042 | 0.76 | MAP4K1 (0.47) | MAPK1MAP4K1IL2CLK1DYRK1A | |
| SCHEMBL30524644 | 0.76 | MAPK1 (0.51) | MAPK1MAP4K1IL2CLK1DYRK1A | |
| SCHEMBL21557641 | 0.75 | MAPK1 (0.48) | MAPK1MAP4K1IL2CLK1DYRK1A | |
| SCHEMBL1487564 | 0.74 | MAP4K1 (0.47) | MAPK1MAP4K1IL2CLK1DYRK1A | |
| SCHEMBL21962024 | 0.73 | MAP4K1 (0.45) | MAPK1MAP4K1IL2CLK1DYRK1A | |
| SCHEMBL22403198 | 0.73 | MAPK1 (0.62) | MAPK1MAP4K1IL2 | |
| SCHEMBL25853355 | 0.73 | MAPK1 (0.59) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212531-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV Discovery (FR) | 2023-07-19 | — | — | EP | disclosed |