Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.57 |
| ▸ | PI4KA | P42356 | 7/20 | 0.57 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.57 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851900 | 0.83 | PIK3CD (0.45) | PIK3CAPI4KAPI4KBPIK3CGPIK3CD | |
| SCHEMBL2669105 | 0.83 | PIK3CD (0.43) | PIK3CAPI4KAPI4KBPIK3CGPIK3CD | |
| SCHEMBL2666814 | 0.83 | PI4KA (0.58) | PIK3CAPI4KAPI4KBPIK3CGPIK3CD | |
| SCHEMBL30526543 | 0.83 | PIK3CD (0.55) | PIK3CAPI4KAPI4KBPIK3CGPIK3CD | |
| SCHEMBL184566 | 0.83 | PIK3CD (0.55) | PIK3CAPI4KAPI4KBPIK3CGPIK3CD | |
| SCHEMBL10233444 | 0.82 | HTR7 (0.46) | PIK3CAPI4KAPI4KBPIK3CGPIK3CD | |
| SCHEMBL3512062 | 0.82 | PIK3CD (0.41) | PIK3CAPI4KAPI4KBPIK3CGPIK3CD | |
| SCHEMBL13408569 | 0.81 | PIK3CD (0.40) | PIK3CAPI4KAPI4KBPIK3CGPIK3CD | |
| SCHEMBL10233497 | 0.81 | PIK3CD (0.40) | PIK3CAPI4KAPI4KBPIK3CGPIK3CD | |
| SCHEMBL184747 | 0.80 | PIK3CD (0.50) | PIK3CAPI4KAPI4KBPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026766-A1 | Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors | BEIGENE, LTD. (KY) | 2025-01-23 | — | — | US | disclosed |
| EP-4463456-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BeiGene, Ltd. (KY) | 2024-11-20 | — | — | EP | disclosed |
| WO-2024230578-A1 | CYCLIC DERIVATIVES, COMPOSITIONS AND USES THEREOF | DANATLAS PHARMACEUTICALS CO., LTD. (CN) | 2024-11-14 | — | — | WO | disclosed |
| CN-118510778-A | Thiazolopyridylamide derivatives as inhibitors of DNA polymerase θ | 百济神州有限公司 | 2024-08-16 | — | — | CN | disclosed |
| WO-2023134708-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BEIGENE , LTD. (KY) | 2023-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026766-A1 | Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors | POLQ, POLK, POLI | PIK3CA 386/4885PI4KA 134/4885PI4KB 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.