Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.61 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3047563 | 0.91 | CHEK1 (0.51) | CHEK1AURKAKDRCDK7 | |
| SCHEMBL3043799 | 0.90 | CHEK1 (0.50) | CHEK1AURKAKDRCDK7 | |
| Hydrochloric Acid SCHEMBL3040239 | 0.88 | CHEK1 (0.66) | CHEK1AURKAKDRCDK7 | |
| SCHEMBL3050085 | 0.87 | CHEK1 (0.54) | CHEK1AURKAKDRCDK7 | |
| Hydrochloric Acid SCHEMBL3046069 | 0.84 | CHEK1 (0.53) | CHEK1AURKAKDRCDK7 | |
| Hydrochloric Acid SCHEMBL3042165 | 0.83 | CHEK1 (0.51) | CHEK1AURKAKDRCDK7 | |
| Hydrochloric Acid SCHEMBL3041699 | 0.83 | CHEK1 (0.56) | CHEK1AURKAKDRCDK7 | |
| Hydrochloric Acid SCHEMBL3041610 | 0.83 | CHEK1 (0.52) | CHEK1AURKAKDRCDK7 | |
| SCHEMBL3047766 | 0.82 | CHEK1 (0.55) | CHEK1AURKAKDRCDK7 | |
| Hydrochloric Acid SCHEMBL3053931 | 0.81 | CHEK1 (0.50) | CHEK1AURKAKDRCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745641-B2 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | NR4A1, NR5A2, PRMT8 | CHEK1 3306/4885AURKA 2312/4885KDR 3226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.