Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BMX | P51813 | 3/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21799069 | 1.00 | JAK2 (0.47) | JAK2JAK3CYP2C9CYP2C19BMX | |
| SCHEMBL30530308 | 0.87 | — | — | |
| SCHEMBL20190513 | 0.87 | — | — | |
| SCHEMBL21799098 | 0.86 | AXL (0.51) | JAK2JAK3DDR1MAPK14KDR | |
| SCHEMBL30530302 | 0.86 | AXL (0.51) | JAK2JAK3DDR1MAPK14KDR | |
| SCHEMBL30114852 | 0.84 | BCHE (0.44) | — | |
| SCHEMBL20187754 | 0.84 | BCHE (0.44) | — | |
| SCHEMBL20191208 | 0.84 | JAK2 (0.58) | JAK2JAK3MAPK14CDK1KDR | |
| SCHEMBL21799068 | 0.81 | — | — | |
| SCHEMBL21799061 | 0.81 | ABL1 (0.41) | JAK2JAK3DDR1ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110139692-B | Heteroaryl amine compounds for modulating hedgehog pathway and methods of making and using the same | 财团法人生物技术开发中心 | 2023-08-25 | — | — | CN | claimed |
| CN-110139692-B | Heteroaryl amine compounds for modulating hedgehog pathway and methods of making and using the same | 财团法人生物技术开发中心 | 2023-08-25 | — | — | CN | disclosed |