Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | BCR | P11274 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21799076 | 1.00 | RAB9A (0.53) | RAB9ANPC1ACKR3HTR2CMCHR1 | |
| SCHEMBL20188084 | 0.92 | ABL1 (0.49) | ACKR3HTR2CMCHR1F10ABL1 | |
| SCHEMBL20188790 | 0.90 | ABL1 (0.51) | RAB9AABL1BCRSMN1; SMN2LMNA | |
| SCHEMBL21799072 | 0.86 | RAB9A (0.51) | RAB9ANPC1ACKR3HTR2CMCHR1 | |
| SCHEMBL30530277 | 0.86 | RAB9A (0.51) | RAB9ANPC1ACKR3HTR2CMCHR1 | |
| SCHEMBL20188677 | 0.85 | BRAF (0.49) | ABL1BCRLMNAMAPK14 | |
| SCHEMBL21799087 | 0.83 | ABL1 (0.47) | ABL1BCRLMNAMAPK14 | |
| SCHEMBL30114739 | 0.83 | ABL1 (0.47) | ABL1BCRLMNAMAPK14 | |
| SCHEMBL21799112 | 0.81 | RAB9A (0.49) | RAB9AABL1BCRLMNAMAPK14 | |
| SCHEMBL30114702 | 0.81 | RAB9A (0.49) | RAB9AABL1BCRLMNAMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110139692-B | Heteroaryl amine compounds for modulating hedgehog pathway and methods of making and using the same | 财团法人生物技术开发中心 | 2023-08-25 | — | — | CN | claimed |
| CN-110139692-B | Heteroaryl amine compounds for modulating hedgehog pathway and methods of making and using the same | 财团法人生物技术开发中心 | 2023-08-25 | — | — | CN | disclosed |