Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.68 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201785 | 0.83 | MAPK13 (0.54) | HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL12684742 | 0.83 | HDAC1 (0.76) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL22798202 | 0.82 | HDAC1 (0.70) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL3777895 | 0.81 | HDAC1 (0.54) | HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL3774831 | 0.81 | HDAC1 (0.53) | HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL14454656 | 0.80 | HDAC1 (0.71) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL17094907 | 0.80 | POLB (0.58) | HDAC1PTGS1 | |
| SCHEMBL4463540 | 0.79 | HDAC1 (0.66) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL2733350 | 0.78 | HDAC1 (0.80) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL2733213 | 0.78 | HDAC1 (0.68) | HDAC1HDAC3HDAC2NCOR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476255-B2 | Histone deacetylase inhibitors | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2013-07-02 | — | — | US | disclosed |
| US-20100222379-A1 | NOVEL HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2010-09-02 | — | — | US | disclosed |
| EP-2205563-A2 | NOVEL HISTONE DEACETYLASE INHIBITORS | Orchid Research Laboratories Limited (IN) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009047615-A2 | NOVEL HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2009-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222379-A1 | NOVEL HISTONE DEACETYLASE INHIBITORS | HDAC5, HDAC2, HDAC1 | HDAC1 3/4885HDAC3 13/4885HDAC2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.