SCHEMBL30535573

SCHEMBL30535573

CCOC(=O)c1cnn(-c2ncccc2N)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.45
NPC1 O15118 4/20 0.45
RAB9A P51151 4/20 0.45
HPGD P15428 3/20 0.45
TP53 P04637 2/20 0.45
ALDH1A1 P00352 5/20 0.43
HSD17B10 Q99714 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.42
TSHR P16473 1/20 0.42
LMNA P02545 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
MAOA P21397 1/20 0.41
KMT2A Q03164 1/20 0.41
ESRRA P11474 1/20 0.41
MAPT P10636 2/20 0.40
HSD11B1 P28845 1/20 0.40
ELANE P08246 2/20 0.40
PDE4A P27815 1/20 0.40
ADORA2A P29274 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25431180 1.00 MAOB (0.45) MAOBNPC1RAB9AHPGDTP53
SCHEMBL28645779 0.84 MAOB (0.47) MAOBNPC1RAB9AHPGDTP53
SCHEMBL30535288 0.81 MAPT (0.54) MAOBNPC1RAB9AHPGDALDH1A1
SCHEMBL25429598 0.81 MAPT (0.54) MAOBNPC1RAB9AHPGDALDH1A1
SCHEMBL12571590 0.80 MAOB (0.46) MAOBNPC1RAB9AHPGDTP53
SCHEMBL25429980 0.80 ALKBH1 (0.47) MAOBNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL30535434 0.79 EGLN1 (0.64) MAOBNPC1RAB9AHPGDTP53
SCHEMBL2159904 0.79 EGLN1 (0.64) MAOBNPC1RAB9AHPGDTP53
SCHEMBL25430596 0.78 NPSR1 (0.47) MAOBNPC1RAB9ATP53SMN1; SMN2
SCHEMBL31561310 0.78 PPIA (0.47) MAOBNPC1RAB9ATP53ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119923385-A Inhibitors of RNA helicase DHX9 and uses thereof 埃克森特治疗公司 2025-05-02 CN disclosed
EP-4479138-A1 INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF Accent Therapeutics, Inc. (US) 2024-12-25 EP disclosed
WO-2023154519-A1 INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF ACCENT THERAPEUTICS, INC. (US) 2023-08-17 WO disclosed