Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25367752 | 1.00 | ABL1 (0.55) | ABL1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL25368459 | 0.93 | NPC1 (0.52) | ABL1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL30543864 | 0.93 | NPC1 (0.52) | ABL1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL25368034 | 0.88 | KMT2A (0.60) | LMNASMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL25367472 | 0.86 | MEN1 (0.53) | RAB9ANR1H4IDH1MAPK1MEN1 | |
| SCHEMBL30543926 | 0.86 | MEN1 (0.53) | RAB9ANR1H4IDH1MAPK1MEN1 | |
| SCHEMBL25368128 | 0.86 | EPHX2 (0.48) | LMNASMN1; SMN2NPC1RAB9AEPHX2 | |
| SCHEMBL30543946 | 0.85 | DHX9 (0.53) | LMNASMN1; SMN2RAB9AMAPK1MEN1 | |
| SCHEMBL25368280 | 0.85 | DHX9 (0.53) | LMNASMN1; SMN2RAB9AMAPK1MEN1 | |
| SCHEMBL25368447 | 0.83 | HPGD (0.51) | LMNASMN1; SMN2NPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4479380-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | Accent Therapeutics, Inc. (US) | 2024-12-25 | — | — | EP | disclosed |
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |