Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30544685 | 1.00 | GSK3B (0.38) | GSK3BLRRK2POLBTRPC5MTOR | |
| SCHEMBL30544672 | 0.80 | HTR3A (0.51) | POLBPARP1TNKS | |
| SCHEMBL30544688 | 0.73 | PARP1 (0.34) | POLBMTORALDH1A1PARP1PRKCI | |
| SCHEMBL30544670 | 0.73 | CHRNA7 (0.39) | POLBCHRNA7KCNH2ALDH1A1PARP1 | |
| SCHEMBL30544681 | 0.71 | MAP4K4 (0.41) | KCNH2ATRATRIPPARP1 | |
| SCHEMBL30544664 | 0.71 | MAP4K4 (0.41) | KCNH2ATRATRIPPARP1 | |
| SCHEMBL30544699 | 0.71 | MAP4K4 (0.41) | KCNH2ATRATRIPPARP1 | |
| SCHEMBL30544663 | 0.71 | ATM (0.42) | LRRK2MTORATR | |
| SCHEMBL30544673 | 0.70 | POLB (0.38) | GSK3BPOLBMTORALDH1A1PARP1 | |
| SCHEMBL30544668 | 0.70 | TIPARP (0.41) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116635371-A | Polycyclic pyridazinone derivative serving as SOS1 inhibitor, and preparation method and application thereof | 苏州阿尔脉生物科技有限公司 | 2023-08-22 | — | — | CN | disclosed |