Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B known ✓ | Q07343 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 4/20 | 0.36 |
| ▸ | AXL | P30530 | 3/20 | 0.36 |
| ▸ | MERTK | Q12866 | 3/20 | 0.36 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.35 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL29248906 | 0.92 | IRAK4 (0.41) | IRAK4MAP4K3MAP3K7TAB1AXL | |
| SCHEMBL24257689 | 0.88 | IRAK4 (0.44) | IRAK4MAP4K3MAP3K7TAB1AXL | |
| SCHEMBL29248903 | 0.86 | IRAK4 (0.41) | IRAK4MAP4K3MAP3K7TAB1AXL | |
| Nitrous Acid SCHEMBL29248905 | 0.85 | IRAK4 (0.42) | IRAK4MAP4K3MAP3K7TAB1AXL | |
| SCHEMBL24257594 | 0.85 | IRAK4 (0.38) | IRAK4MAP4K3PDE4BAXLMERTK | |
| SCHEMBL24257541 | 0.78 | IRAK4 (0.44) | IRAK4MAP4K3USP1ALKKDM4E | |
| Glycine SCHEMBL30546864 | 0.74 | JAK2 (0.44) | ALDH1A1JAK2JAK3 | |
| SCHEMBL24257696 | 0.73 | TNK2 (0.48) | MAP3K7TAB1MET | |
| SCHEMBL24257712 | 0.72 | MEN1 (0.48) | MET | |
| SCHEMBL30452371 | 0.72 | MEN1 (0.48) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |