Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30452371 | 1.00 | MEN1 (0.48) | MEN1KMT2ATNK2LMNATHRB | |
| SCHEMBL24257696 | 0.88 | TNK2 (0.48) | TNK2LMNATHRBMETTTK | |
| SCHEMBL24257594 | 0.87 | IRAK4 (0.38) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL24257786 | 0.86 | MET (0.44) | MEN1KMT2ATNK2LMNATHRB | |
| SCHEMBL30546843 | 0.86 | MET (0.44) | MEN1KMT2ATNK2LMNATHRB | |
| SCHEMBL30453163 | 0.82 | TNK2 (0.47) | TNK2METGPR119TTK | |
| SCHEMBL24257799 | 0.82 | TNK2 (0.47) | TNK2METGPR119TTK | |
| SCHEMBL24257505 | 0.80 | TNK2 (0.45) | TNK2LMNAMETTDP1L3MBTL1 | |
| SCHEMBL24257745 | 0.79 | GRM4 (0.42) | MEN1KMT2ATP53L3MBTL1 | |
| SCHEMBL24257538 | 0.78 | KMT2A (0.39) | MEN1KMT2ALMNATDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |