SCHEMBL30551237

SCHEMBL30551237

C[C@H]1CC[C@H](c2ccc3scnc3c2)N(C(=O)C(=O)Nc2cncc3cn[nH]c23)C1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 20/20 0.65
WDR77 Q9BQA1 3/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25323138 1.00 PRMT5 (0.65) PRMT5WDR77
SCHEMBL30551102 0.86 PRMT5 (0.68) PRMT5WDR77
SCHEMBL30551487 0.86 PRMT5 (0.66) PRMT5WDR77
SCHEMBL25323323 0.86 PRMT5 (0.66) PRMT5WDR77
SCHEMBL25322350 0.86 PRMT5 (0.68) PRMT5WDR77
SCHEMBL25323331 0.86 PRMT5 (0.66) PRMT5WDR77
SCHEMBL30551426 0.85 PRMT5 (0.59) PRMT5WDR77
SCHEMBL25319964 0.85 PRMT5 (0.59) PRMT5WDR77
SCHEMBL30551531 0.85 PRMT5 (0.59) PRMT5WDR77
SCHEMBL25320474 0.85 PRMT5 (0.48) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4469455-A1 COMPOUNDS AND METHODS OF USE Tango Therapeutics, Inc. (US) 2024-12-04 EP disclosed
WO-2023146990-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. (US) 2023-08-03 WO disclosed