Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Suramin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY11 | Q96G91 | 9/20 | 1.00 |
| ▸ | RECQL | P46063 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 1.00 |
| ▸ | HPSE | Q9Y251 | 5/20 | 1.00 |
| ▸ | TIMP3 | P35625 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | PKM | P14618 | 4/20 | 1.00 |
| ▸ | P2RX1 | P51575 | 4/20 | 1.00 |
| ▸ | P2RX3 | P56373 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | USP2 | O75604 | 2/20 | 1.00 |
| ▸ | BRCA1 | P38398 | 2/20 | 1.00 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 1.00 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 1.00 |
| ▸ | ENPP3 | O14638 | 1/20 | 1.00 |
| ▸ | ENTPD3 | O75355 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Suramin SCHEMBL29357785 | 1.00 | P2RY11 (1.00) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| Suramin SCHEMBL30312075 | 1.00 | P2RY11 (1.00) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| Suramin SCHEMBL29371906 | 1.00 | P2RY11 (1.00) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| Suramin SCHEMBL3161 | 1.00 | P2RY11 (1.00) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL21686991 | 0.97 | P2RY11 (0.95) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL20370854 | 0.95 | P2RY11 (0.90) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL32686687 | 0.93 | P2RY11 (0.87) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL16404704 | 0.93 | P2RY11 (0.86) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL3358966 | 0.92 | RECQL (1.00) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL30392305 | 0.92 | RECQL (1.00) | P2RY11RECQLKMT2AHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118103072-A | Methods of treating neurological disorders using anticholinergic agents | 帕克斯医学有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-116802174-A | Intranasal administration of suramin for the treatment of neurological disorders | 帕克斯医学有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-116744914-A | Administration of anti-purinergic compositions for the treatment of neurological disorders | 帕克斯医学有限公司 | 2023-09-12 | — | — | CN | disclosed |