Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 14/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | ATXN2 | Q99700 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3051878 | 0.93 | ENPP2 (0.78) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3057996 | 0.91 | ENPP2 (0.81) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL171685 | 0.90 | ENPP2 (0.86) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL171674 | 0.89 | ENPP2 (1.00) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL15147374 | 0.89 | ENPP2 (0.80) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3054826 | 0.88 | ENPP2 (0.85) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL169993 | 0.88 | ENPP2 (0.79) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL172139 | 0.88 | ENPP2 (0.75) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL171648 | 0.87 | ENPP2 (0.82) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3055238 | 0.86 | ENPP2 (0.79) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791111-B2 | Piperidine and piperazine derivatives | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | claimed |
| EP-2426106-B1 | Piperidine and Piperazine derivatives for the treatment of tumours | MERCK PATENT GMBH (DE) | 2013-07-31 | — | — | EP | claimed |
| US-20100222341-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HARTUNG (DE) | 2010-09-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222341-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | CCND2, CCND1, TPD52L2 | ENPP2 3706/4885KCNH2 66/4885GRIN2D 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.