Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 12/20 | 0.59 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | AKT2 | P31751 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20916798 | 1.00 | MAPK1 (0.59) | MAPK1MAPK3ROCK2ROCK1MAPK13 | |
| SCHEMBL20931407 | 1.00 | MAPK1 (0.59) | MAPK1MAPK3ROCK2ROCK1MAPK13 | |
| SCHEMBL30554291 | 0.93 | ROCK1 (0.53) | MAPK1MAPK3ROCK2ROCK1MAPK13 | |
| SCHEMBL20916842 | 0.93 | ROCK1 (0.53) | MAPK1MAPK3ROCK2ROCK1MAPK13 | |
| SCHEMBL22284218 | 0.92 | MAPK1 (0.55) | MAPK1MAPK3TACR3 | |
| SCHEMBL30554335 | 0.92 | MAPK1 (0.55) | MAPK1MAPK3TACR3 | |
| SCHEMBL20920102 | 0.92 | MAPK1 (0.49) | MAPK1MAPK3ROCK2ROCK1MAPK13 | |
| SCHEMBL20931757 | 0.92 | MAPK1 (0.55) | MAPK1MAPK3TACR3 | |
| SCHEMBL30554370 | 0.92 | MAPK1 (0.49) | MAPK1MAPK3ROCK2ROCK1MAPK13 | |
| SCHEMBL20916830 | 0.91 | MAPK1 (0.69) | MAPK1MAPK3ROCK2ROCK1RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112020357-B | Salt of indazolyl-containing tricyclic derivative and crystal form thereof | 上海翰森生物医药科技有限公司 | 2023-08-29 | — | — | CN | disclosed |