Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22284368 | 1.00 | BACE1 (0.37) | BACE1BACE2PDE2AROCK2MAPK1 | |
| SCHEMBL22284367 | 1.00 | BACE1 (0.37) | BACE1BACE2PDE2AROCK2MAPK1 | |
| SCHEMBL22284300 | 0.95 | ROCK2 (0.42) | PDE2AROCK2MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL30554287 | 0.95 | ROCK2 (0.42) | PDE2AROCK2MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL22284303 | 0.95 | ROCK2 (0.42) | PDE2AROCK2MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL30554296 | 0.94 | PDE2A (0.44) | PDE2AROCK2MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL22284158 | 0.94 | PDE2A (0.44) | PDE2AROCK2MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL22284157 | 0.94 | PDE2A (0.44) | PDE2AROCK2MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL22284254 | 0.93 | PHGDH (0.39) | PDE2AROCK2MAPK1RPS6KA5MAP4K4 | |
| SCHEMBL22284255 | 0.93 | PHGDH (0.39) | PDE2AROCK2MAPK1RPS6KA5MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112020357-B | Salt of indazolyl-containing tricyclic derivative and crystal form thereof | 上海翰森生物医药科技有限公司 | 2023-08-29 | — | — | CN | disclosed |