Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21910251 | 1.00 | TACR1 (0.34) | TACR1GPR119MEN1KMT2AMMP13 | |
| SCHEMBL30554422 | 0.92 | KMT2A (0.37) | TACR1GPR119MEN1KMT2AMMP13 | |
| SCHEMBL21910267 | 0.92 | KMT2A (0.37) | TACR1GPR119MEN1KMT2AMMP13 | |
| SCHEMBL30554424 | 0.92 | KMT2A (0.37) | TACR1GPR119MEN1KMT2AMMP13 | |
| SCHEMBL21911495 | 0.88 | TACR1 (0.38) | TACR1GPR119MEN1KMT2AMMP13 | |
| SCHEMBL25327934 | 0.87 | MAPK14 (0.33) | RORCMAPTMAPK1RAB9A | |
| SCHEMBL21831342 | 0.87 | MAPK14 (0.33) | RORCMAPTMAPK1RAB9A | |
| SCHEMBL21910374 | 0.84 | TACR1 (0.37) | TACR1GPR119MEN1KMT2AMMP13 | |
| SCHEMBL30554486 | 0.84 | TACR1 (0.37) | TACR1GPR119MEN1KMT2AMMP13 | |
| SCHEMBL25138125 | 0.81 | TACR1 (0.40) | TACR1GPR119MEN1KMT2AMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B9 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3814348-B1 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |