Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | KIT | P10721 | 3/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21831342 | 1.00 | MAPK14 (0.33) | MAPK14KITCACNA1BMAPTRORC | |
| SCHEMBL21831643 | 0.90 | L3MBTL1 (0.36) | MAPK14MAPT | |
| SCHEMBL25327588 | 0.90 | L3MBTL1 (0.36) | MAPK14MAPT | |
| SCHEMBL21910251 | 0.87 | TACR1 (0.34) | MAPTRORCMAPK1RAB9A | |
| SCHEMBL30554407 | 0.87 | TACR1 (0.34) | MAPTRORCMAPK1RAB9A | |
| SCHEMBL21831016 | 0.82 | MAPK14 (0.37) | MAPK14KITCACNA1BDPP4DPP8 | |
| SCHEMBL25327867 | 0.82 | MAPK14 (0.37) | MAPK14KITCACNA1BDPP4DPP8 | |
| SCHEMBL25328563 | 0.79 | PDK1 (0.39) | MAPTRORC | |
| SCHEMBL21831336 | 0.79 | PDK1 (0.39) | MAPTRORC | |
| SCHEMBL21831526 | 0.78 | ALDH1A1 (0.38) | MAPK14MAPTTSHRDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B9 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3814348-B1 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |