SCHEMBL30554609

SCHEMBL30554609

Cc1c(Cl)cc(C(C)(C)C)c(O)c1C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX1 P51575 9/20 0.51
P2RX7 Q99572 5/20 0.51
TMPRSS4 Q9NRS4 4/20 0.51
P2RX4 Q99571 4/20 0.51
TLR7 Q9NYK1 1/20 0.51
JUN P05412 5/20 0.48
NFKB1 P19838 5/20 0.48
NFKB2 Q00653 5/20 0.48
RELA Q04206 5/20 0.48
IKBKB O14920 2/20 0.46
MEN1 O00255 1/20 0.46
CHUK O15111 1/20 0.46
KDR P35968 1/20 0.46
FLT3 P36888 1/20 0.46
KMT2A Q03164 1/20 0.46
MYLK Q15746 1/20 0.46
MAP4K5 Q9Y4K4 1/20 0.46
XPO1 O14980 1/20 0.46
IKBKE Q14164 1/20 0.44
MAPT P10636 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3241964 1.00 P2RX1 (0.51) P2RX1P2RX7TMPRSS4P2RX4TLR7
SCHEMBL26214027 0.88 P2RX1 (0.53) P2RX1P2RX7TMPRSS4P2RX4TLR7
SCHEMBL30554617 0.83 KDR (0.54) TMPRSS4MEN1KDRKMT2AMAPT
SCHEMBL3246689 0.83 KDR (0.54) TMPRSS4MEN1KDRKMT2AMAPT
SCHEMBL17413358 0.82 NR1H4 (0.50) TMPRSS4KDRMAPT
SCHEMBL30554581 0.81 TMPRSS4 (0.54) TMPRSS4MEN1KDRKMT2AMAPT
SCHEMBL3242642 0.81 TMPRSS4 (0.54) TMPRSS4MEN1KDRKMT2AMAPT
SCHEMBL2788022 0.78 NR1H4 (0.43) P2RX1MEN1KMT2AMAPT
SCHEMBL30554602 0.78 AR (0.49)
SCHEMBL3235641 0.78 AR (0.49)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4483376-A1 MEASUREMENT, DIAGNOSIS, TREATMENT AND MANAGEMENT OF METABOLIC SYNDROME García Sada, Fernando (MX) 2025-01-01 EP claimed
CN-118922890-A Measurement, diagnosis, treatment and management of metabolic syndrome 费尔南多·加西亚·萨达 2024-11-08 CN claimed
WO-2023161832-A1 MEASUREMENT, DIAGNOSIS, TREATMENT AND MANAGEMENT OF METABOLIC SYNDROME GARCIA SADA FERNANDO (MX) 2023-08-31 WO claimed
EP-4483376-A1 MEASUREMENT, DIAGNOSIS, TREATMENT AND MANAGEMENT OF METABOLIC SYNDROME García Sada, Fernando (MX) 2025-01-01 EP disclosed
US-20240066001-A1 METHODS AND COMPOSITIONS FOR TREATING OBESITY, PREVENTING WEIGHT GAIN, PROMOTING WEIGHT LOSS, PROMOTING SLIMMING, OR TREATING OR PREVENTING THE DEVELOPMENT OF DIABETES SILTI AG (CH) 2024-02-29 US disclosed
WO-2023161832-A1 MEASUREMENT, DIAGNOSIS, TREATMENT AND MANAGEMENT OF METABOLIC SYNDROME GARCIA SADA FERNANDO (MX) 2023-08-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240066001-A1 METHODS AND COMPOSITIONS FOR TREATING OBESITY, PREVENTING WEIGHT GAIN, PROMOTING WEIGHT LOSS, PROMOTING SLIMMING, OR TREATING OR PREVENTING THE DEVELOPMENT OF DIABETES GPR119, CPT1B, CPT2 P2RX1 2486/4885P2RX7 2018/4885TMPRSS4 4382/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.