SCHEMBL305577

SCHEMBL305577

CC(C)OC(=O)C(O)CC(=O)O

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.48
SLC22A6 Q4U2R8 1/20 0.40
TSHR P16473 2/20 0.39
LMNA P02545 2/20 0.37
HCAR2 Q8TDS4 1/20 0.35
MAPT P10636 1/20 0.35
ALOX15 P16050 1/20 0.35
GABRR1 P24046 2/20 0.34
CACNA2D1 P54289 2/20 0.33
CACNB3 P54284 1/20 0.33
CACNA1C Q13936 1/20 0.33
PGR P06401 1/20 0.33
ADRA1A P35348 1/20 0.33
HTR2B P41595 1/20 0.33
CACNA2D2 Q9NY47 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
PGD P52209 1/20 0.32
GPR84 Q9NQS5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31289248 1.00 SMN1; SMN2 (0.48) SMN1; SMN2SLC22A6TSHRLMNAHCAR2
SCHEMBL19359076 1.00 SMN1; SMN2 (0.48) SMN1; SMN2SLC22A6TSHRLMNAHCAR2
SCHEMBL5586418 0.86 SMN1; SMN2 (0.48) SMN1; SMN2SLC22A6LMNAMAPTALOX15
SCHEMBL29613 0.83 SMN1; SMN2 (0.50) SMN1; SMN2SLC22A6LMNAMAPTALOX15
SCHEMBL16928436 0.83 SMN1; SMN2 (0.44) SMN1; SMN2SLC22A6TSHRLMNAMAPT
SCHEMBL2246742 0.82 LMNA (0.41) SMN1; SMN2TSHRLMNAHCAR2MAPT
SCHEMBL1828782 0.82 LMNA (0.41) SMN1; SMN2TSHRLMNAHCAR2MAPT
SCHEMBL918978 0.82 LMNA (0.41) SMN1; SMN2TSHRLMNAHCAR2MAPT
SCHEMBL29929853 0.82 LMNA (0.41) SMN1; SMN2TSHRLMNAHCAR2MAPT
SCHEMBL30754373 0.82 CPT2 (0.42) SMN1; SMN2PGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 214 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119372168-A Recombinant microorganism for high leucine production and construction method and application thereof 清华大学 2025-01-28 CN claimed
CN-119193658-A Method for improving yield of isoamyl alcohol produced by yarrowia lipolytica through mitochondrial compartmentalization 郑州大学 2024-12-27 CN claimed
CN-117757705-B Construction and application of genetic engineering strain capable of realizing co-production of branched-chain amino acid 元素驱动(杭州)生物科技有限公司 2024-12-20 CN claimed
CN-117757704-B Method for improving yield of Branched Chain Amino Acid (BCAA) and strain construction 元素驱动(杭州)生物科技有限公司 2024-08-27 CN claimed
CN-118240726-A Escherichia coli engineering bacteria utilizing sucrose or molasses and method for producing branched chain amino acid by fermentation of escherichia coli engineering bacteria 元素驱动(杭州)生物科技有限公司 2024-06-25 CN claimed
CN-118126917-A Genetically engineered strain for strengthening co-production of L-isoleucine and L-valine and application thereof 元素驱动(杭州)生物科技有限公司 2024-06-04 CN claimed
CN-117887649-A Leucine production strain, construction method and application thereof 江苏元易邦生物科技有限公司 2024-04-16 CN claimed
CN-117757705-A Construction and application of genetic engineering strain capable of realizing co-production of branched-chain amino acid 元素驱动(杭州)生物科技有限公司 2024-03-26 CN claimed
CN-117757704-A Method for improving yield of Branched Chain Amino Acid (BCAA) and strain construction 元素驱动(杭州)生物科技有限公司 2024-03-26 CN claimed
EP-4320253-A1 SYNTHESIS OF BETA-HYDROXYISOVALERATE AND METHODS OF USE Sasya Inc. (US) 2024-02-14 EP claimed
CN-116987722-A Cephalotaxus hainanensis isopropyl malic acid synthetase IPMS1 and application thereof 中国热带农业科学院热带作物品种资源研究所 2023-11-03 CN claimed
CN-116529254-A Phosphonate products and methods 伊利诺伊大学董事会 2023-08-01 CN claimed
CN-116355818-A Genetically engineered bacterium for producing L-leucine and application thereof 天津科技大学 2023-06-30 CN claimed
CN-109790554-B Method for preparing elongated 2-keto acids and C5-C10 compounds thereof by genetic modification of metabolic pathways in microorganisms 陶氏环球技术有限责任公司 2023-06-16 CN claimed
CN-116262914-A 3-isopropyl malate dehydratase mutant and application thereof 廊坊梅花生物技术开发有限公司 2023-06-16 CN claimed
WO-2022216868-A1 SYNTHESIS OF BETA-HYDROXYISOVALERATE AND METHODS OF USE Sasya Inc. (US) 2022-10-13 WO claimed
US-20220127311-A1 CELL FACTORIES FOR IMPROVED PRODUCTION OF COMPOUNDS AND PROTEINS DEPENDENT ON IRON SULFUR CLUSTERS BIOSYNTIA APS (DK) 2022-04-28 US claimed
EP-3911666-A1 CELL FACTORIES FOR IMPROVED PRODUCTION OF COMPOUNDS AND PROTEINS DEPENDENT ON IRON SULFUR CLUSTERS Biosyntia ApS (DK) 2021-11-24 EP claimed
WO-2020148351-A1 CELL FACTORIES FOR IMPROVED PRODUCTION OF COMPOUNDS AND PROTEINS DEPENDENT ON IRON SULFUR CLUSTERS BIOSYNTIA APS (DK) 2020-07-23 WO claimed
US-20100129886-A1 PRODUCTION OF ISOBUTANOL IN YEAST MITOCHONDRIA BUTAMAX (TM) ADVANCED BIOFUELS LLC (US) 2010-05-27 US claimed