Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 4/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21664261 | 1.00 | PTGS1 (0.45) | PTGS1PTGS2ENPP1HRH4BTK | |
| SCHEMBL25551955 | 0.87 | ENPP1 (0.44) | PTGS1PTGS2ENPP1HRH4BTK | |
| SCHEMBL26554820 | 0.85 | HRH4 (0.42) | PTGS1PTGS2HRH4BTKSCN10A | |
| SCHEMBL21664272 | 0.84 | ENPP1 (0.47) | PTGS1PTGS2ENPP1HRH4BTK | |
| SCHEMBL30562879 | 0.84 | ENPP1 (0.47) | PTGS1PTGS2ENPP1HRH4BTK | |
| Hydrochloric Acid SCHEMBL30562890 | 0.83 | ENPP1 (0.46) | PTGS1PTGS2ENPP1HRH4BTK | |
| SCHEMBL21664262 | 0.83 | ENPP1 (0.49) | PTGS1PTGS2ENPP1SCN10ASIRT2 | |
| SCHEMBL30562932 | 0.83 | ENPP1 (0.49) | PTGS1PTGS2ENPP1SCN10ASIRT2 | |
| SCHEMBL21664248 | 0.82 | PRKDC (0.47) | PTGS1PTGS2ENPP1HRH4BTK | |
| SCHEMBL21664314 | 0.79 | AURKA (0.41) | ENPP1BTKNAMPTKHKRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |