Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 8/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | AKT2 | P31751 | 2/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21664278 | 1.00 | LMNA (0.46) | LMNAHTTSMN1; SMN2HRH1HRH3 | |
| SCHEMBL24064750 | 0.86 | HTT (0.47) | HTTPRKDCPDE3A | |
| SCHEMBL21664279 | 0.85 | GBA1 (0.42) | SMN1; SMN2GBA1JAK2JAK3 | |
| SCHEMBL26558270 | 0.82 | LMNA (0.47) | LMNAHTTSMN1; SMN2HRH1HRH3 | |
| SCHEMBL21664309 | 0.81 | LMNA (0.50) | LMNAHTTSMN1; SMN2HRH1HRH3 | |
| SCHEMBL21664350 | 0.79 | HTT (0.44) | HTTPRKDCPDE3A | |
| SCHEMBL30562915 | 0.79 | HTT (0.44) | HTTPRKDCPDE3A | |
| SCHEMBL21664242 | 0.78 | ENPP1 (0.50) | LMNAHTTPDE3A | |
| SCHEMBL24703572 | 0.76 | CHRM4 (0.42) | PRKDC | |
| SCHEMBL21664230 | 0.75 | LMNA (0.51) | LMNAHTTSMN1; SMN2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |