Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 5/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21664253 | 1.00 | ENPP1 (0.58) | ENPP1MTNR1BKITPDE3APDE10A | |
| SCHEMBL25552110 | 0.90 | ENPP1 (0.47) | ENPP1MTNR1BKITPDE3APDE10A | |
| SCHEMBL21664318 | 0.89 | ENPP1 (0.49) | ENPP1MTNR1BKITPDE3APDE10A | |
| SCHEMBL25551755 | 0.87 | ENPP1 (0.49) | ENPP1PDGFRBPRKDC | |
| SCHEMBL21664268 | 0.86 | ENPP1 (0.71) | ENPP1PDE3APDE10APDE3BHTR1A | |
| SCHEMBL21664403 | 0.86 | HTT (0.50) | ENPP1PDGFRBPRKDC | |
| SCHEMBL30562980 | 0.86 | ENPP1 (0.48) | ENPP1PDE3APDGFRBPRKDC | |
| SCHEMBL30562899 | 0.86 | HTT (0.50) | ENPP1PDGFRBPRKDCPIK3CDPIK3CA | |
| SCHEMBL21664244 | 0.86 | ENPP1 (0.48) | ENPP1PDE3APDGFRBPRKDC | |
| SCHEMBL21664258 | 0.86 | HTT (0.50) | ENPP1PDGFRBPRKDCPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |