Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25406780 | 1.00 | NPC1 (0.42) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL26847516 | 0.84 | HPGDS (0.39) | NPC1RAB9ASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL25409385 | 0.79 | KLK3 (0.57) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL13974502 | 0.78 | MAPT (0.66) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL30567672 | 0.78 | KCNH2 (0.48) | MAPTMEN1KMT2APIK3CAPIK3CD | |
| SCHEMBL25406855 | 0.78 | KCNH2 (0.48) | MAPTMEN1KMT2APIK3CAPIK3CD | |
| SCHEMBL2689845 | 0.76 | CYP2A6 (0.54) | MEN1CYP2C19CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2684541 | 0.76 | MAP4K4 (0.46) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL13860615 | 0.75 | UHRF1 (0.35) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL1852996 | 0.73 | KLK3 (0.44) | NPC1RAB9AMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116615425-A | Compounds and compositions as Sppl2a inhibitors | 诺华股份有限公司 | 2023-08-18 | — | — | CN | disclosed |