Sugi Predict

Sugi Predict / Compounds / SCHEMBL30567773

SCHEMBL30567773

SCHEMBL30567773

CSCC[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CN)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O

nearest known ligand 0.65

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ CRHR1 P34998 1/20 0.65
▸ CRHR2 Q13324 1/20 0.65
▸ CALCR P30988 4/20 0.64
▸ HCRTR1 O43613 1/20 0.58
▸ HCRTR2 O43614 1/20 0.58
▸ GLP1R P43220 3/20 0.56
▸ GCGR P47871 3/20 0.56
▸ NTSR1 P30989 1/20 0.54
▸ NPY2R P49146 6/20 0.53
▸ NPY4R P50391 6/20 0.53
▸ NPY5R Q15761 6/20 0.53
▸ NPY1R P25929 4/20 0.53
▸ CXCL8 P10145 1/20 0.53
▸ F2 P00734 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30567751 0.93 CALCR (0.71) CRHR1CRHR2CALCRHCRTR1HCRTR2
SCHEMBL30906485 0.87 CALCR (0.67) CRHR1CRHR2CALCRHCRTR1HCRTR2
SCHEMBL30567728 0.86 GLP1R (0.63) CRHR1CRHR2CALCRHCRTR1HCRTR2
SCHEMBL30567698 0.86 GLP1R (0.63) CRHR1CRHR2CALCRHCRTR1HCRTR2
SCHEMBL29949623 0.85 CRHR1 (0.68) CRHR1CRHR2CALCRHCRTR1HCRTR2
SCHEMBL31182677 0.85 CALCR (0.78) CRHR1CRHR2CALCRHCRTR1HCRTR2
SCHEMBL31130603 0.85 MC4R (0.56) CRHR1CRHR2CALCRHCRTR1HCRTR2
SCHEMBL31182603 0.84 CALCR (0.62) CRHR1CRHR2CALCRNPY2RNPY4R
SCHEMBL31130616 0.83 MC4R (0.57) CRHR1CRHR2CALCRHCRTR1HCRTR2
SCHEMBL31182732 0.83 CALCR (0.69) CRHR1CRHR2CALCRHCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240277841-A2 HUMAN CHIMERIC ANTIGEN RECEPTOR NEUTROPHILS, COMPOSITIONS, KITS AND METHODS OF USE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-08-22 — — US disclosed
US-20240024473-A1 HUMAN CHIMERIC ANTIGEN RECEPTOR NEUTROPHILS, COMPOSITIONS, KITS AND METHODS OF USE PURDUE RESEARCH FOUNDATION (US) 2024-01-25 — — US disclosed
CN-116601290-A Human chimeric antigen receptor neutrophils, compositions, kits and methods of use 普渡研究基金会 2023-08-15 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240277841-A2 HUMAN CHIMERIC ANTIGEN RECEPTOR NEUTROPHILS, COMPOSITIONS, KITS AND METHODS OF USE PBK, KIT, MYD88 CRHR1 1859/4885CRHR2 2419/4885CALCR 889/4885
US-20240024473-A1 HUMAN CHIMERIC ANTIGEN RECEPTOR NEUTROPHILS, COMPOSITIONS, KITS AND METHODS OF USE PBK, KIT, MYD88 CRHR1 1859/4885CRHR2 2419/4885CALCR 889/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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