Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KCNJ1 | P48048 | 6/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475649 | 1.00 | MAPT (0.51) | MAPTLMNAKCNJ1TP53JAK1 | |
| SCHEMBL20945406 | 0.87 | KCNJ1 (0.58) | KCNJ1 | |
| SCHEMBL30569154 | 0.87 | KCNJ1 (0.58) | KCNJ1 | |
| SCHEMBL30569204 | 0.85 | KCNJ1 (0.46) | KCNJ1 | |
| SCHEMBL19475689 | 0.85 | KCNJ1 (0.46) | KCNJ1 | |
| SCHEMBL19475834 | 0.83 | KCNJ1 (0.53) | MAPTLMNAKCNJ1TP53 | |
| SCHEMBL30569153 | 0.82 | KCNJ1 (0.57) | MAPTLMNAKCNJ1TP53 | |
| SCHEMBL20945399 | 0.82 | KCNJ1 (0.57) | MAPTLMNAKCNJ1TP53 | |
| SCHEMBL19512957 | 0.77 | KCNJ1 (0.57) | MAPTLMNAKCNJ1 | |
| SCHEMBL30569189 | 0.77 | KCNJ1 (0.57) | MAPTLMNAKCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3445762-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2023-09-13 | — | — | EP | claimed |
| EP-3445762-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2023-09-13 | — | — | EP | disclosed |