Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 18/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475915 | 1.00 | KCNJ1 (0.55) | KCNJ1KCNH2P2RX3P2RX2PRMT5 | |
| SCHEMBL19512839 | 0.91 | KCNJ1 (0.46) | KCNJ1KCNH2P2RX3P2RX2 | |
| SCHEMBL20945405 | 0.76 | KCNJ1 (0.72) | KCNJ1KCNH2 | |
| SCHEMBL19475764 | 0.73 | KCNJ1 (0.65) | KCNJ1KCNH2 | |
| SCHEMBL20945425 | 0.72 | KCNJ1 (0.47) | KCNJ1KCNH2PRMT5WDR77 | |
| SCHEMBL19475679 | 0.72 | KCNJ1 (0.58) | KCNJ1KCNH2 | |
| SCHEMBL19475769 | 0.71 | KCNJ1 (1.00) | KCNJ1KCNH2PRMT5WDR77 | |
| SCHEMBL19475854 | 0.70 | KCNJ1 (0.84) | KCNJ1KCNH2 | |
| SCHEMBL19512840 | 0.69 | ESR2 (0.50) | KCNJ1 | |
| SCHEMBL14790616 | 0.67 | KCNJ1 (0.60) | KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3445762-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2023-09-13 | — | — | EP | claimed |