Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 2/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 4/20 | 0.41 |
| ▸ | FPR2 | P25090 | 4/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19512840 | 0.86 | ESR2 (0.50) | KCNJ1S1PR1MEN1KMT2ANPC1 | |
| SCHEMBL20945423 | 0.85 | KCNJ1 (0.53) | KCNJ1S1PR1FPR1FPR2TMPRSS2 | |
| SCHEMBL17797510 | 0.76 | TMPRSS2 (0.53) | HSD17B3TMPRSS2KMT2AALDH1A1NPC1 | |
| SCHEMBL20537078 | 0.75 | HSD17B3 (0.53) | HSD17B3TMPRSS2MEN1KMT2AALDH1A1 | |
| SCHEMBL19475800 | 0.75 | DRD2 (0.46) | KCNJ1ROCK2ALDH1A1 | |
| SCHEMBL1951535 | 0.73 | KMT2A (0.48) | S1PR1HSD17B3TMPRSS2MEN1KMT2A | |
| SCHEMBL19475915 | 0.72 | KCNJ1 (0.55) | KCNJ1PRMT5WDR77KCNH2 | |
| SCHEMBL30569171 | 0.72 | KCNJ1 (0.55) | KCNJ1PRMT5WDR77KCNH2 | |
| SCHEMBL5600099 | 0.72 | KMT2A (0.45) | S1PR1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL29097825 | 0.72 | ERCC1 (0.43) | TMPRSS2MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3445762-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2023-09-13 | — | — | EP | disclosed |
| US-10851108-B2 | Substituted bicyclic heterocyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-12-01 | — | — | US | disclosed |
| US-20190127380-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127380-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS | NR0B1, GRK4, CRKL | KCNJ1 245/4885S1PR1 1190/4885HSD17B3 711/4885 |
| US-10851108-B2 | Substituted bicyclic heterocyclic compounds | NR0B1, GRK4, CRKL | KCNJ1 245/4885S1PR1 1190/4885HSD17B3 711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.