Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13379880 | 0.98 | IDH1 (0.33) | IDH1SOS1SOS2POLBTDP1 | |
| SCHEMBL29349121 | 0.94 | IDH1 (0.31) | IDH1 | |
| SCHEMBL13379878 | 0.89 | — | — | |
| SCHEMBL31416318 | 0.82 | OPRM1 (0.31) | — | |
| SCHEMBL21584269 | 0.78 | — | — | |
| SCHEMBL22052765 | 0.76 | CYP2D6 (0.35) | POLB | |
| SCHEMBL25100292 | 0.72 | IDH1 (0.39) | IDH1 | |
| SCHEMBL12240400 | 0.69 | — | — | |
| SCHEMBL14376295 | 0.68 | PIK3CD (0.41) | IDH1 | |
| SCHEMBL29348282 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116583285-A | N- (imidazo [1,2-b ] pyridazin-3-yl) -1-cyclohexyl-2H-indazole-5-carboxamide and N- (pyrazolo [1,5-a ] pyrimidin-3-yl) -1-cyclohexyl-2H-indazole-5-carboxamide derivatives as IRAK4 inhibitors for the treatment of asthma | 阿斯利康(瑞典)有限公司 | 2023-08-11 | — | — | CN | disclosed |