Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.44 |
| ▸ | FEN1 | P39748 | 5/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26117499 | 0.90 | GPR119 (0.43) | ALOX5APFEN1GPR119SMARCA2SMARCA4 | |
| SCHEMBL26117491 | 0.90 | GPR119 (0.43) | ALOX5APFEN1GPR119SMARCA2SMARCA4 | |
| SCHEMBL18186269 | 0.86 | NR1H2 (0.42) | GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL18186168 | 0.86 | NR1H2 (0.42) | GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL16824920 | 0.86 | NR1H2 (0.42) | GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL25738402 | 0.86 | GPR119 (0.49) | GPR119 | |
| SCHEMBL25738403 | 0.84 | MEN1 (0.45) | GPR119 | |
| SCHEMBL30176849 | 0.84 | SMARCA2 (0.54) | ALOX5APFEN1GPR119SMARCA2SMARCA4 | |
| SCHEMBL14924376 | 0.84 | SMARCA2 (0.54) | ALOX5APFEN1GPR119SMARCA2SMARCA4 | |
| SCHEMBL30512308 | 0.84 | SMARCA2 (0.54) | ALOX5APFEN1GPR119SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4480482-A2 | PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE | AbbVie Inc. (US) | 2024-12-25 | — | — | EP | disclosed |
| EP-4249073-B1 | PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE | ABBVIE INC (US) | 2024-12-11 | — | — | EP | disclosed |
| EP-4249073-A1 | PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE | AbbVie Inc. (US) | 2023-09-27 | — | — | EP | disclosed |